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Menthol is either derived naturally from peppermint or other mint oils or synthetically manufactured. When used as an active ingredient in over-the-counter (OTC) medicines, menthol has a number of different uses. Depending on the dose and form, menthol can be used to relieve coughs; help control plaque or kill bacteria that can contribute to the development of gingivitis; relieve oral discomfort associated with canker sores, injury of the mouth and gums, sore throat, fever blisters, or cold sores; relieve minor aches and pains of muscles and joints; and relieve irritated lips and skin.
When taken orally or used topically in or around the mouth, menthol can be the only ingredient in topical cough suppressant medicines (such as lozenges or sprays) or it can be combined with other ingredients in oral multi-symptom cough and cold medicines, anti-gingivitis and anti-plaque products, or oral discomfort products. Products used externally for topical pain relief may contain either menthol alone or menthol in combination with other active ingredients. Menthol can also be combined with other active ingredients in cough suppressant medicines (such as chest rubs and steam vaporizers) and skin protectants.
Symptoms Treated
Symptoms Treated
More specifically:
Cough, Plaque or bacteria in the mouth that can contribute to gingivitis, Oral discomfort, Sore throat, Minor aches and pains and Irritated lips and skin
Common Products
For cough and sore throat:
- Buckley’s®
- Cēpacol®
- Fisherman’s Friend®
- Sucrets®
- Vicks®
For minor aches and pains:
- BENGAY®
- BOROLEUM®
- Deep Heating®
- Mentholatum®
- Satogesic®
- Stopain®
For plaque or bacteria in the mouth:
- Chloraseptic®
- LISTERINE®
For irritated lips and skin:
- Carmex®
- GOLD BOND®
- Palmer’s®
For oral discomfort:
- Orajel™
Additional store brands (ex. Walmart’s “Equate” store brand or CVS Health store brand)
Dosing Information
Different types of products containing this active ingredient have different strengths. That’s why it is always important to read and follow the Drug Facts label. Most medicines warn against use of an active ingredient for longer than 7-10 days. Stop use and ask a doctor if symptoms persist.
A Note to Families:
1. Scientific and medical authorities around the world recognize acetaminophen as the only analgesic considered safe for use throughout an entire pregnancy when used according to the Drug Facts label.
2. There are no studies showing that acetaminophen use in children or during pregnancy causes autism.
3. Autism has many known risk factors, including genetics, but there is no clear, single cause.
4. Major health authorities like the FDA, CDC, and healthcare organizations such as the American College of Obstetricians and Gynecologists (ACOG) do not have warnings against acetaminophen use during pregnancy based on any known risk of autism and all recommend acetaminophen as the safest analgesic to use during pregnancy for short-term pain relief.
Frequently Asked Questions:
In fact, the Autism Science Foundation (ASF), a non-profit organization funding scientific autism research, specifically states that: it is disingenuous and misleading to boil autism's causes down to one simple thing," as there are hundreds of genes linked to autism in addition to other complex environmental factors.
Additionally, the most recent and rigorous research on this topic does not show a causal link to autism. The 2024 study published in the Journal of the American Medical Association (JAMA) analyzed nearly 2.5 million children using the gold-standard sibling comparison method, which controls for shared genetics and family environment, and found no association between acetaminophen use during pregnancy or infancy and neurodevelopmental issues such as autism.
- CDC Yellow Book (Current as of April 23, 2025): “Acetaminophen remains the non-opioid analgesic of choice during pregnancy.”
- FDA’s Acetaminophen Page (Current as of August 14, 2025): “To date, FDA has not found clear evidence that appropriate use of acetaminophen during pregnancy causes adverse pregnancy, birth, neurobehavioral, or developmental outcomes.”
Additionally, the Society for Maternal-Fetal Health, a professional organization for obstetricians with subspecialty training in maternal-fetal medicine, stated on September 25, 2025 that it: "...continues to advise physicians and patients that acetaminophen is an appropriate medication to treat pain and fever during pregnancy…the weight of scientific evidence that acetaminophen use during pregnancy causes an increased risk for autism or ADHD is simply inconclusive…”
Safety Guide
Safety Guide
Menthol is approved by the U.S. Food and Drug Administration (FDA) and is safe and effective when used according to the Drug Facts label.
Safe use tips for cough or sore throat medicines:
- Topical cough suppressant lozenges should be placed in the mouth and dissolved slowly. You should never swallow a lozenge whole.
Safe use tips for mouth rinses:
- Anti-gingivitis and anti-plaque products should not be swallowed.
Safe use tips for topical medicines to treat minor aches and pains:
- Medicines intended to be applied to the skin should not be swallowed.
- Certain products may be flammable. Keep away from open flame.
- You should never heat, microwave, or add the medicine to hot water.
- You should not bandage tightly or use a heating pad on the treated area.
- You should avoid getting the product into your eyes, nose, or mouth.
- You should not apply to wounds or damaged skin.
Ask a healthcare provider before use if:
For cough or sore throat medicines:
- You are pregnant or breastfeeding.
For topical medicines to treat minor aches and pains:
- You are pregnant or breastfeeding.
For oral discomfort medicines:
- Talk to a healthcare provider before using an oral discomfort product containing menthol with a child under the age of 2. Children between the ages of 2 and 12 should be supervised when using these medicines.
Do not use if:
For cough and sore throat medicines:
- Do not give cough suppressant lozenges to young children.
- Do not give an oral OTC cough medicine or multi-symptom cough and cold product to a child under the age of 4.
For mouth rinses and oral discomfort medicines:
- Do not use an anti-gingivitis or anti-plaque mouth rinse containing menthol with a child under the age of 12.
- Talk to a healthcare provider before using an oral discomfort product containing menthol with a child under the age of 2. Children between the ages of 2 and 12 should be supervised when using these medicines.
Stop use and ask a doctor if:
For cough and sore throat medicines:
- Your cough persists for more than 7 days, tends to recur, or is accompanied by a fever, rash, or persistent headache.
- Your symptoms do not improve, get worse, or if you develop additional symptoms.
- You take too much or you accidentally ingest a medicine that is not intended to be swallowed. Immediately contact a healthcare provider or the poison control national helpline at 800.222.1222.
For mouth rinses:
- You have painful or swollen gums.
- Gingivitis, bleeding, or redness persists for more than two weeks.
- Your symptoms do not improve, get worse, or if you develop additional symptoms.
- You take too much or you accidentally ingest a medicine that is not intended to be swallowed. Anti-gingivitis and anti-plaque products should not be swallowed if you are using a mouth rinse containing menthol. Immediately contact a healthcare provider or the poison control national helpline at 800.222.1222.
What are the side effects of menthol?
- Although rare, get emergency medical help if you have signs of an allergic reaction from oral or topical application of menthol: hives, difficulty breathing, or swelling of your face, lips, tongue, or throat.
